CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Mechanical ventilation-induced apoptosis in newborn rat lung is mediated via FasL/Fas pathway
نویسندگان
چکیده
Andreas A. Kroon, Veronica DelRiccio, Irene Tseu, Brian P. Kavanagh, and Martin Post Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Canada; Department of Pediatrics, Erasmus MC-Sophia, Rotterdam, The Netherlands; Departments of Critical Care Medicine and Anesthesia, Hospital for Sick Children, University of Toronto, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; and Department of Pediatrics, University of Toronto, Toronto, Canada
منابع مشابه
Mechanical ventilation-induced apoptosis in newborn rat lung is mediated via FasL/Fas pathway.
Mechanical ventilation induces pulmonary apoptosis and inhibits alveolar development in preterm infants, but the molecular basis for the apoptotic injury is unknown. The objective was to determine the signaling mechanism(s) of ventilation (stretch)-induced apoptosis in newborn rat lung. Seven-day-old rats were ventilated with room air for 24 h using moderate tidal volumes (8.5 ml/kg). Isolated ...
متن کاملInduction of interleukin-8 secretion and apoptosis in bronchiolar epithelial cells by Fas ligation.
Epithelial cell injury is the common manifestation of lung injury. Contributing to such injury of epithelial cells is apoptosis. Although apoptosis is part of the normal process of epithelial renewal, in excess it is pathologic. We previously demonstrated the excessive apoptosis of lung epithelial cells and the upregulation of Fas and Fas ligand (FasL) in fibrosing lung diseases. We also showed...
متن کاملEpithelial cell apoptosis by fas ligand-positive myofibroblasts in lung fibrosis.
The Fas/Fas ligand (FasL) apoptotic pathway has been shown to be involved in bleomycin-induced lung fibrosis. We examined the hypothesis that myofibroblasts from fibrotic lungs possess a cytotoxic phenotype that causes apoptosis of epithelial cells via the Fas/FasL pathway. We show in vivo epithelial cell apoptosis and associated upregulation of Fas and apoptotic Fas pathway genes in epithelial...
متن کاملCALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Alterations in expression of elastogenic and angiogenic genes by different conditions of mechanical ventilation in newborn rat lung
Kroon AA, Wang J, Post M. Alterations in expression of elastogenic and angiogenic genes by different conditions of mechanical ventilation in newborn rat lung. Am J Physiol Lung Cell Mol Physiol 308: L639 –L649, 2015. First published January 23, 2015; doi:10.1152/ajplung.00293.2014.—Mechanical ventilation is an important risk factor for development of bronchopulmonary dysplasia. Here we investig...
متن کاملCALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Exposure to mechanical ventilation promotes tolerance to ventilator-induced lung injury by Ccl3 downregulation
Jorge Blázquez-Prieto, Inés López-Alonso, Laura Amado-Rodríguez, Estefanía Batalla-Solís, Adrián González-López, and Guillermo M. Albaiceta Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain; Área de Gestión Clínica de Medicina Intensiva, Hospital Valle del Nalón, Langreo, Spain; Department of Anesthesiology ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013